Jiangsu Bioperfectus Technologies Co., Ltd.

Monkeypox, a contagious disease caused by the monkeypox virus, is now officially referred to as mpox by the World Health Organization (WHO). This change in terminology was implemented to address concerns that the previous name could be interpreted as racially insensitive. Mpox remains a significant and ongoing challenge to global public health. As of June 5, 2023, WHO has reported an alarming total of 87,929 laboratory-confirmed cases and an extra 1,095 probable cases. The virus has devastatingly resulted in 146 deaths. Heightening the concern, two cases of mpox were reported in Beijing, China on June 6, 2023. Confirmed cases of mpox from 1 Jan 2022, as of 05 Jun 2023 Transmission Mpox is a zoonosis, a disease that is transmitted from animals to humans. The disease can also spread from humans to humans. It can be transmitted through contact with bodily fluids, lesions on the skin or on internal mucosal surfaces, such as in the mouth or throat, respiratory droplets and contaminated objects. Mpox virus can be spread to the fetus during pregnancy or to the newborn by close contact during and after birth. Symptoms The incubation period of mpox can range from 5 to 21 days. The febrile stage of illness usually lasts 1 to 3 days with symptoms including fever, intense headache, lymphadenopathy (swelling of the lymph nodes), back pain, myalgia (muscle ache), and an intense asthenia (lack of energy). The febrile stage is followed by the skin eruption stage, lasting for 2 to 4 weeks. Lesions evolve from macules (lesions with a flat base) to papules (raised firm painful lesions) to vesicles (filled with clear fluid) to pustules (filled with pus), followed by scabs or crusts. The proportion of patients who die has varied between 0 and 11% in documented cases and has been higher among young children. Treatment There are no treatments specifically for mpox. The goal of treating mpox is to take care of the rash, manage pain and prevent complications. Early and supportive care is important to help manage symptoms and avoid further problems. Most people with mpox will recover within 2 to 4 weeks. Prevention Minimize contact with individuals infected with mpox, and maintain frequent hand hygiene using soap or hand sanitizers. Avoid unguarded interaction with wild animals, particularly those ill or deceased, and ensure animal-based food products are well-cooked. For those infected with mpox, isolation is critical until complete lesion healing occurs to prevent virus transmission. Abide by local health guidelines on home or facility-based isolation. Diagnosis According to the official diagnostic guidelines provided by the World Health Organization (WHO), the detection of viral DNA by polymerase chain reaction (PCR) is the preferred laboratory test for mpox. The best diagnostic specimens are taken directly from the rash skin, fluid or crusts collected by vigorous swabbing. In the absence of skin lesions, testing can be done on oropharyngeal, anal or rectal swabs. Testing blood is not recommended. Antibody detection methods may not be useful as they do not distinguish between different orthopoxviruses. BioPerfectus has developed a suite of tests for detecting the mpox virus and possesses extensive experience in the prevention and control of mpox disease on a global scale. During the mpox outbreak in Africa, BioPerfectus collaborated closely with the Africa Centres for Disease Control and Prevention (Africa CDC), African Union, and the African Society for Laboratory Medicine (ASLM), supplying critical testing kits and offering our technical expertise. This vital contribution played a significant role in successfully containing the epidemic in the region. Additionally, BioPerfectus maintains a long-term collaboration with the Chinese government. It has supplied emergency reserve test kits for numerous significant events, including the G20 Summit, the 93rd Military Parade, the Qingdao SCO Summit, and the Beijing Winter Olympics. BioPerfectus has also been a leading supplier from China, providing the global market with a significant number of Monkeypox Virus Real Time PCR Kits. Given the worldwide spread of the mpox virus, our expert response team remains vigilant and ready, poised to provide immediate support to affected regions. By offering comprehensive Total PCR Solutions, including instruments and kits, BioPerfectus stands ready to contribute to the prevention and management of infectious diseases, including the mpox virus. Reference: 1. https://www.bjcdc.org/article/78739/2023/6/1686056380752.html 2. https://www.who.int/news-room/fact-sheets/detail/monkeypox 3. https://worldhealthorg.shinyapps.io/mpx_global/ 4. https://www.cdc.gov/poxvirus/mpox/if-sick/transmission.html 5. https://www.cdc.gov/poxvirus/mpox/if-sick/treatment.html 6. https://www.who.int/news-room/questions-and-answers/item/monkeypox 7. https://www.who.int/news-room/fact-sheets/detail/monkeypox

Tick-borne diseases pose a significant threat as the predominant vector-borne illnesses in temperate regions of North America, Europe, and Asia. In the United States, ticks account for over 95% of reported vector-borne disease cases. Among these, Lyme disease stands out as the most widespread tick-borne illness in the northern hemisphere. Studies suggest that the actual number of Lyme disease cases exceeds the reported figures by around 10-fold, with an estimated 300,000 annual diagnoses in the USA alone. Additionally, although roughly 10,000 cases of other tick-borne diseases are officially reported each year, it is highly likely that the actual number of cases far surpasses this count. Furthermore, their impact is exacerbated by climate and environmental changes. These changes are anticipated to increase the prevalence of ticks, thereby heightening the risk of these diseases. Overall, tick-borne diseases pose a substantial burden on global health, necessitating urgent attention. Addressing the challenge of tick-borne illnesses is crucial for ensuring the protection of public health worldwide. Map of Lyme Disease Incidence Rates (Reported Cases per 100,000 People) Understanding Tick-Borne Diseases Tick-borne diseases are a group of illnesses transmitted to humans through infected tick bites. Common tick-borne diseases include Crimean-Congo Hemorrhagic Fever, Tick-borne Encephalitis, Severe Fever with Thrombocytopenia Syndrome, Anaplasmosis, Bartonellosis, Lyme Disease, Q Fever, Tularemia, Human Monocytic Ehrlichiosis, Heilongjiang Tick Typhus, etc. Symptoms often include fever, fatigue, headache, muscle and joint aches, swollen lymph nodes, and a characteristic skin rash. In severe cases, complications can affect the joints, heart, and nervous system. Causes of Tick-Borne Diseases Tick-borne diseases are caused by various pathogens, including bacteria, parasites, and viruses, which are transmitted by infected ticks. The specific pathogens and diseases vary by geographic region and tick species. For Example: Tick-borne Encephalitis: Tick-borne encephalitis is primarily caused by the Tick-borne Encephalitis Virus, which belongs to the Flaviviridae family. This virus is transmitted by infected ticks, primarily Ixodes ricinus and Ixodes persulcatus, in Europe and Asia. Crimean-Congo Hemorrhagic Fever: Crimean-Congo Hemorrhagic Fever is caused by the Crimean-Congo Hemorrhagic Fever Virus, which is a member of the Nairovirus genus in the Bunyaviridae family. This virus is transmitted through the bite of infected ticks, primarily Hyalomma species ticks. How to Identify Tick-Borne Diseases Identifying tick-borne diseases can be done through serological testing, PCR, or culture methods. Among these, PCR testing plays a crucial role in the early detection of tick-borne diseases. Tick-borne diseases, including tick-borne encephalitis virus (TBEV), can be detected in the early stages of the disease course using PCR testing. RT-PCR, in particular, enables the detection of TBEV RNA in serum and cerebrospinal fluid (CSF) samples prior to the appearance of antibodies. PCR testing allows for swift and accurate diagnosis, enabling timely treatment and management of tick-borne diseases. Prevention and Control for Tick-Borne Diseases Prevention measures include wearing protective clothing, using insect repellents, avoiding tick-infested areas, and performing thorough tick checks. If a tick is found attached, it should be carefully removed using tweezers, followed by cleaning the area. Seeking medical attention is important if symptoms develop after a tick bite, as healthcare professionals can provide diagnosis, treatment, and guidance on managing tick bites and preventing further infections. What Can BioPerfectus Provide for Tick-Borne Diseases Prevention and Control? Accurate diagnosis of the cause is essential because each tick-borne disease requires different treatments, and it is challenging to differentiate these diseases based on symptoms alone. BioPerfectus offers a range of real-time PCR kits for the early identification and diagnosis of tick-borne diseases such as Tick-borne Encephalitis, Crimean-Congo Hemorrhagic Fever, and Lyme disease. Our products deliver reliable results without cross-reactivity. BioPerfectus is committed to supporting the prevention and control of infectious diseases by providing Total PCR Solutions, including instruments and reagents. Join the fight against tick-borne diseases with BioPerfectus Real-Time PCR Kits. Learn more about our Tick-Borne Diseases products: https://www.bioperfectus.com/ProductList?C=102 References: 1. https://www.cdc.gov/ticks/index.html 2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451033/ 3. https://www.sciencedirect.com/science/article/abs/pii/S1386653206003192 4. https://www.canada.ca/en/public-health/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2019-45/issue-4-april-4-2019/article-2-increased-risk-tick-borne-diseases-climate-change.html 5. https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0260122.g001

Today, we spotlight the remarkable journey of BioPerfectus's global footprint, a testament to our significant growth and expansion. Our unwavering commitment to global health has been the guiding force, reinforcing our mission, "BioPerfectus, for a healthier future". Our international strategy has been pivotal in our success, with the establishment of subsidiaries in strategic locations such as the United States, Hong Kong, and the United Kingdom. This strategic expansion has enabled us to cater to various markets and meet our customers' diverse needs more effectively. In times of global health crises, BioPerfectus has played a crucial role, contributing significantly to the fight against major pandemics such as COVID-19, Monkeypox, and Ebola. Our unwavering commitment and demonstrated responsibility during these critical periods are sources of immense pride. The dedicated efforts of our partners and employees have significantly contributed to our success story. Their experiences and collaborations have fostered strong relationships and driven the mutual growth that is at the heart of BioPerfectus's global footprint. As we acknowledge our achievements, we also envision a future brimming with opportunities. Our CEO, Dr. Guoqiang Wang, provides a clear vision for BioPerfectus's future and our ongoing development plans. His inspiring words motivate our team and partners to rise above challenges and achieve more. In recognition of this significant journey, we express our deepest gratitude to our dedicated team and partners. Your commitment and passion have turned our shared vision into reality, and for that, we say, "Thank you!" We move forward with an unwavering commitment to our mission, ready to seize the opportunities of tomorrow. As we continue to acknowledge our past successes and eagerly anticipate a future full of growth, innovation, and contribution to global health, we affirm our unity as BioPerfectus. Together, let's forge ahead towards a healthier future!